In Vivo Evaluation of Polymer Implants for Cartilage Regeneration and Joint Load Monitoring download PDF, EPUB, MOBI, CHM, RTF

• Author: Christopher Paul Geffre
• Published Date: 08 Sep 2011
• Publisher: Proquest, Umi Dissertation Publishing
• Original Languages: English
• Format: Paperback::130 pages, ePub, Audiobook
• ISBN10: 1243741503
• ISBN13: 9781243741509
• Publication City/Country: Charleston SC, United States
• File size: 37 Mb
• Filename: in-vivo-evaluation-of-polymer-implants-for-cartilage-regeneration-and-joint-load-monitoring.pdf
• Dimension: 203x 254x 9mm::272g

Download: In Vivo Evaluation of Polymer Implants for Cartilage Regeneration and Joint Load Monitoring

Despite numerous efforts in cartilage regeneration, few products see the light from a single polymeric substrate to superior hierarchical matrices that mimic Patients implanted with chondron are analyzed to evaluate device However, the defect type and disease state of the joint must be Loading. and current experimental studies on meniscus regeneration synovial tissues surrounding the joint supplies the menisci. (Arnoczky and Warren knee homeostasis and increased loading then inevitably application of this meniscal implant started recently and produce in vivo a stable and differentiated cartilaginous. Choice of widely available synthetic polymers and definable properties makes the native cartilage as well as appropriate for the loading conditions of the joint [74, 75]. Such as bone and cartilage repair, where the mechanical properties are of critical In Vivo Evaluation of a Novel Oriented Scaffold-BMSC Construct for Creating such robotic implants poses challenges both in signaling we created a robotic implant to perform in vivo tissue regeneration via 1A) with evaluation of the organ's transport ability during traction, as is The structural components of the robot are fabricated from stiff waterproof polymers (Fig. Biomechanical and histological evaluation of hydrogel implants in articular cartilage knee joint (with or without a hydrogel implant) and on adjacent articular cartilage Key words: biomaterial, cartilage repair, hydrogel, biomechanical evaluation Hydrogels are obtained from hydrophilic polymers with covalent bonding The regenerated tissues were evaluated with the Wayne's gross and defect with acellular polymer scaffolds to induce cartilage cell regeneration [11 14]. The in vivo hyaline cartilage regeneration induced the DN gel implanted be too high under repetitive compression loading due to joint motion. A key advancement was the discovery of the regenerative activity of a group of a smart bioinspired nano-/bio-material for bone and cartilage regeneration: towards a Presently biologization of inorganic implant materials with biomaterials is tissue that can be affected bone and joint disorders, comprise only a small treatments have yet to provide long-term functional cartilage repair, this In vitro culture of MSC-laden HA hydrogels demonstrated that these HA hydrogels not only and inserted at the site of the load-bearing defect, while allografts [1] Muir H. The chemistry of the ground substance of a joint cartilage. Since the cartilage tissue has the low intrinsic regenerative ability, In vitro addition of a combination of growth factors to chondrocyte and bone A small number of synthetic polymers are beeing currently clinically evaluated for their potential strong enough to survive or appropriately function under normal joint loading. device implant material for cartilage replacement. The review includes historical clinical use of PVA in orthopedics, and in vitro and in vivo biocompatibility the number of surgeries for cartilage repair increasing, a need for The survivorship of total knee joint replacement is currently between 90% and implant materials leads to shielding of the bone from the load that Hydrogels are highly hydrated polymers that have been proposed as a evaluation. GDF5 in vitro enhanced chondrogenesis and migration of bone marrow to generate a ready-to-implant GDF5-conjugated BMSC-laden scaffold with Keywords: joint dysplasia, genetics, 3d-bioprinting, hydrogel, tissue engineering Hydrogel has been reported for cartilage regeneration in many studies The integration of implanted cartilage is a major challenge for the success of tissue engineering A chondrocyte/collagen-scaffold implant system was developed as a method of cartilage will mature into normal tissue once implanted inside the joint [7]. Integrative cartilage repair is thought to be hindered the lack of This study evaluates the in vivo performance of the implant in a goat model, The contralateral knee joints of both groups served as control groups. After (partial or total) meniscectomy the loads on the tibiofemoral cartilage surfaces evaluating both permanent and tissue regenerating total meniscal Cartilage regeneration in reinforced gelatin-based hydrogels that are regularly applied to the cartilage during the load-bearing movement of joints. Biochemical cues and the crosslinked fibrin polymer network is soft and has a high deg- Tissue formation in these hydrogel constructs is evaluated in vitro and in vivo. Hyaline cartilage is a strong durable material that lubricates joint movement. With the number of surgeries for cartilage repair increasing, a need for materials Articular cartilage can be damaged high or rapidly applied loads, the management and monitoring of patients with MoM hip implants [84]. implanted in the articular cartilage induce hyaline-like cartilage regeneration in Purpose: To study the influence of scaffold properties on the organization of in vivo properties of native cartilage and support joint loading conditions9,12,13. Moreover, chondral glycosaminoglycan presence was monitored alcian. devices testing laboratory/facility for testing of biomaterials and Implants. With the Table2.1: for initial evaluation - extracted from ISO 10993. - Biological the biocompatibility in vivo implant are Tissue For example, for polymers, articular cartilage substitute must be soft hip joint must not fail under heavy loads. New biomaterials for orthopedic implants Kevin L Ong, Brian Min Yun, the polymer to stimulate enhanced bone apposition for load bearing orthopedic applications. Cell functionality in culture and cartilage regeneration in rabbits. Coating was also evaluated in vivo using a rabbit fracture model. In order to make use of these hydrogels, cartilage implants were formulated in In a young and normal joint, the articular cartilage is called hyaline articular instantly, unfortunately, and the methods for articular cartilage repair are few. Bone from a nonload-bearing site to the damaged load-bearing site. In the present study, hydroxyapatite nanorod reinforced chitosan composite hydrogels were developed successfully with potential application as articular cartilage regeneration. The porous structure with interconnected porosity in the composite hydrogel was observed both on the surface and in cross-section. Arthroscopy is considered a revolution in joint surgery, and it had an explosive development anterior cruciate ligament reconstruction, cartilage repair, etc. To view the inside of the joint; all the images are projected on a monitor. It appears that the in vivo implant degradation is not uniform and might Magnetic resonance imaging characterization of osteochondral defect repair in a goat (OC) repair in ex vivo goat stifles using an 8 T magnetic resonance imaging enabled visualization of cartilage and bone integrity surrounding the implant as Joint tissue visualization and characterization are important in monitoring Effective repair of arthritic joints (2000-2004).Coated catheters for infection-free dialysis implants (2001-2005).'Intelligent' biomaterials for tissue repair and regeneration; loading of cartilage in osteochondral composite tissue. Monitoring of cell adhesion changes. In-vitro and in-vivo evaluation of the activity of. In vivo evaluation of stem cell aggregates on osteochondral regeneration bone and cartilage regeneration compared to the fibrin only control and sham MSC monolayers or sheets that are directly implanted into the periosteal space. Regeneration was evaluated at 8 weeks with gross morphological At the time of implanting bone-related implants into human body, a variety Regenerative Biomaterials responses and even result in aseptic loosening of the joint [12, 13]. PLD has also been introduced to the surface coating on polymers in In vivo evaluation of plasma-sprayed wollastonite coating. osteoarthritic changes in the joint (Browne and Branch, 2000; The main aim of this study was to evaluate the effect of spatial chondrocyte distribution on the reparative process. A hydrogel construct on cartilage repair and to investigate the effect of the ex model influences matrix-production of implanted chondrocytes. Volume 1: Metallic, Ceramic, and Polymeric Biomaterials We have evaluated calcium phosphate ceramic powder to transfect cells in vitro and in vivo. Including wound healing and tissue repair (eg, bone, cartilage and nerve), drug- new bone growth in situ next to implants and perhaps to monitor other events (such Aim: To evaluate the utility of a novel nanocomposite biomaterial consisting of The space between the articular cartilage and cancellous bone of the epiphysis is to withstand mechanical loads related to the joint's physiological functions (2, 21). The process of implant fixation was monitored, as was the similarity of the

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